ACP could inhibit this signal and protect dopaminergic neurons, which might be promising in research of PD therapeutics.Ħ-OHDA Antrodia camphorata polysaccharide Parkinsons disease dopaminergic neuronal. Our study validated that 6-OHDA could induce apoptosis of dopaminergic neurons via ROS-NLRP3 activation. Animal experiments also confirmed that ACP intervention could reduce the activation level of ROS-NLRP3 in the substantia nigra-striatum and improve the exercise capacity of PD mice. ACP could inhibit the expression of ROS-NLRP3 induced by 6-OHDA, exerting a protective role in MES23.5 cells. Therefore, in this study, we focused on ROS-NLRP3 signal to investigate the mechanism of 6-OHDA-induced apoptosis of dopaminergic neurons MES23.5 and the protective effects of ACP on dopaminergic neurons.Ħ-OHDA could further activate the expression of inflammasome NLRP3 by inducing ROS, thereby resulting in apoptosis of MES23.5 cells. Our team previously found that Antrodia camphorata polysaccharide (ACP) exerted a good behavioral improvement effect on the PD mouse model established by 6-OHDA however, the mechanism remains unknown. 6-Hydroxydopamine (6-OHDA), a neurotoxic substance, mediates apoptosis of dopaminergic neurons and causes Parkinson-like symptoms in mice. The main pathological change is the apoptosis of dopaminergic neurons in the substantia nigra pars compacta (SNPc), thereby leading to dopamine reduction in nigral striatum. You can even download MP3 songs for offline listening.Parkinson's disease (PD) is a common degenerative disease of the central nervous system (CNS). Songs are the best way to live the moments or reminisce the memories and thus we at Wynk strive to enhance your listening experience by providing you with high-quality MP3 songs & lyrics to express your passion or to sing it out loud. Along with it if you are looking for a podcast online to keep you motivated throughout the week, then check out the latest podcast of Podcast. With Wynk Music, you will not only enjoy your favourite MP3 songs online, but you will also have access to our hottest playlists such as English Songs, Hindi Songs, Malayalam Songs, Punjabi Songs, Tamil Songs, Telugu Songs. Wynk Music brings to you Tenu Nachdi Vekhna MP3 song from the movie/album JOGIA MANINDER SHINDA. Amrik Talwi, Sachin Ahuja, Maninder Shinda
0 kommentar(er)
